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GENETICS AND GENOMICS IN MEDICINE

sis sis sis basic genetics relevant to health and disease basic genetics relevant to health and disease basic genetics relevant to health and disease

Tom Strachan, Judith Goodship and Patrick Chinnery, all at Newcastle University, UK June 2014 • Paperback • £46.00 500pp • 270 illus • ISBN: 978-0-8153-4480-3

plains technological advances and how they are significant to medicine plains technological advances and how they are significant to medicine cludes up-to-date knowledge about the role of genetics in complex diseases plains technological advances and how they are significant to medicine cludes up-to-date knowledge about the role of genetics in complex diseases cal disorder boxes give detailed insight into the role of genetics in specific diseases cludes up-to-date knowledge about the role of genetics in complex diseases cal disorder boxes give detailed insight into the role of genetics in specific diseases cludes pharmacogenetics and how genetic knowledge can be used in therapy and cal disorder boxes give detailed insight into the role of genetics in specific diseases cludes pharmacogenetics and how genetic knowledge can be used in therapy and cludes pharmacogenetics and how genetic knowledge can be used in therapy and sive problems and solutions for each chapter sive problems and solutions for each chapter sive problems and solutions for each chapter

This new textbook explains the science behind the uses of genetics and genomics in medicine today. It is not just about rare inherited and chromosomal disorders, but how genetics affects the whole spectrum of human health and disease. DNA technologies are explained, with emphasis on the modern techniques that have revolutionized the use of genetic information in medicine and are indicating the role of genetics in common diseases. Other new advances, such as the role of epigenetics and non-coding RNA are given in-depth coverage. The discussion on genetic approaches to treatment includes pharmacogenomics and the prospects for personalized medicine. Cancers are essentially genetic diseases and are given a dedicated chapter that includes new insights from cancer genome sequencing. The final chapter on genetic testing and ethics also covers important developments in clinical and public health genomics. Clinical disorders are covered throughout and there are extensive end-of-chapter questions and problems.

on genetic approaches to treatment includes pharmacogenomics and the prospects for personalized medicine. Cancers are essentially genetic diseases and are given a dedicated chapter that includes new insights from cancer genome sequencing. The final chapter on genetic testing and ethics also covers important developments in clinical and public health genomics. Clinical disorders are covered throughout and there are extensive end-of-chapter questions and problems.

Contents 1. Fundamentals of DNA, Chromosomes and Cells 2. Fundamentals of Gene Structure, Gene Expression and Human Genome Organization 3. Principles Underlying Core DNA Technologies 4. Principles of Genetic Variation 5. Single Gene Disorders: Inheritance Patterns, Phenotype Variability and Allele Frequencies 6. Principles of Gene Regulation and Epigenetics 7. Disease-Causing Abnormalities in DNA and Chromosomes 8. Identifying Disease Genes and Genetic Susceptibility to Common Disease 9. Genetic Approaches to Treating Disease 10. Cancer Genetics and Genomics 11. Genetic Testing From Genes to Genomes and the Ethics of Genetic Testing and Therapy

For more information and to order, please visit

For more information and to order, please visit www.garlandscience.com/ggm.

www.garlandscience.com/ggm.

Also of Interest: Human Molecular Genetics, Fourth Edition

Tom Strachan and Andrew Read

Human Molecular Genetics is an established and class-proven textbook for upper-level undergraduates and graduate students which provides an authoritative and integrated approach to the molecular aspects of human genetics. While maintaining the hallmark features of previous editions, the Fourth Edition has been completely updated. It includes new Key Concepts at the beginning of each chapter and annotated further reading at the conclusion of each chapter, to help readers navigate the wealth of information in this subject. 2010 • Paperback • £52.00 781pp • 610 illus • ISBN: 978-0-8153-4149-9

www.garlandscience.com www.garlandscience.com www.garlandscience.com